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Proteome and Phosphoproteome Analysis of Brown Adipocytes Reveals That RICTOR Loss Dampens Global Insulin/AKT Signaling

Stimulating brown adipose tissue (BAT) activity represents a promising therapy for overcoming metabolic diseases. mTORC2 is important for regulating BAT metabolism, but its downstream targets have not been fully characterized. In this study, we apply proteomics and phosphoproteomics to investigate t...

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Vydáno v:Mol Cell Proteomics
Hlavní autoři: Entwisle, Samuel W., Martinez Calejman, Camila, Valente, Anthony S., Lawrence, Robert T., Hung, Chien-Min, Guertin, David A., Villén, Judit
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Biochemistry and Molecular Biology 2020
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7338085/
https://ncbi.nlm.nih.gov/pubmed/32234964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.RA120.001946
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