Proteome and Phosphoproteome Analysis of Brown Adipocytes Reveals That RICTOR Loss Dampens Global Insulin/AKT Signaling

Stimulating brown adipose tissue (BAT) activity represents a promising therapy for overcoming metabolic diseases. mTORC2 is important for regulating BAT metabolism, but its downstream targets have not been fully characterized. In this study, we apply proteomics and phosphoproteomics to investigate t...

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Detalhes bibliográficos
Publicado no:Mol Cell Proteomics
Main Authors: Entwisle, Samuel W., Martinez Calejman, Camila, Valente, Anthony S., Lawrence, Robert T., Hung, Chien-Min, Guertin, David A., Villén, Judit
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2020
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7338085/
https://ncbi.nlm.nih.gov/pubmed/32234964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.RA120.001946
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