CryoEM structures of human CMG–ATPγS–DNA and CMG–AND-1 complexes

DNA unwinding in eukaryotic replication is performed by the Cdc45–MCM–GINS (CMG) helicase. Although the CMG architecture has been elucidated, its mechanism of DNA unwinding and replisome interactions remain poorly understood. Here we report the cryoEM structure at 3.3 Å of human CMG bound to fork DN...

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Vydáno v:Nucleic Acids Res
Hlavní autoři: Rzechorzek, Neil J, Hardwick, Steven W, Jatikusumo, Vincentius A, Chirgadze, Dimitri Y, Pellegrini, Luca
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2020
Témata:
Structural Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7337937/
https://ncbi.nlm.nih.gov/pubmed/32453425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa429
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