CryoEM structures of human CMG–ATPγS–DNA and CMG–AND-1 complexes

DNA unwinding in eukaryotic replication is performed by the Cdc45–MCM–GINS (CMG) helicase. Although the CMG architecture has been elucidated, its mechanism of DNA unwinding and replisome interactions remain poorly understood. Here we report the cryoEM structure at 3.3 Å of human CMG bound to fork DN...

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Detalles Bibliográficos
Publicado en:Nucleic Acids Res
Main Authors: Rzechorzek, Neil J, Hardwick, Steven W, Jatikusumo, Vincentius A, Chirgadze, Dimitri Y, Pellegrini, Luca
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2020
Assuntos:
Structural Biology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7337937/
https://ncbi.nlm.nih.gov/pubmed/32453425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa429
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