CryoEM structures of human CMG–ATPγS–DNA and CMG–AND-1 complexes

DNA unwinding in eukaryotic replication is performed by the Cdc45–MCM–GINS (CMG) helicase. Although the CMG architecture has been elucidated, its mechanism of DNA unwinding and replisome interactions remain poorly understood. Here we report the cryoEM structure at 3.3 Å of human CMG bound to fork DN...

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Veröffentlicht in:Nucleic Acids Res
Hauptverfasser: Rzechorzek, Neil J, Hardwick, Steven W, Jatikusumo, Vincentius A, Chirgadze, Dimitri Y, Pellegrini, Luca
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2020
Schlagworte:
Structural Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7337937/
https://ncbi.nlm.nih.gov/pubmed/32453425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa429
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