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CryoEM structures of membrane pore and prepore complex reveal cytolytic mechanism of Pneumolysin
Many pathogenic bacteria produce pore-forming toxins to attack and kill human cells. We have determined the 4.5 Å structure of the ~2.2 MDa pore complex of pneumolysin, the main virulence factor of Streptococcus pneumoniae, by cryoEM. The pneumolysin pore is a 400 Å ring of 42 membrane-inserted mono...
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| Yayımlandı: | eLife |
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| Asıl Yazarlar: | , , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
eLife Sciences Publications, Ltd
2017
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5437283/ https://ncbi.nlm.nih.gov/pubmed/28323617 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.23644 |
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