Membrane perforation by the pore-forming toxin pneumolysin

Pneumolysin (PLY), a major virulence factor of Streptococcus pneumoniae, perforates cholesterol-rich lipid membranes. PLY protomers oligomerize as rings on the membrane and then undergo a structural transition that triggers the formation of membrane pores. Structures of PLY rings in prepore and pore...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Vögele, Martin, Bhaskara, Ramachandra M., Mulvihill, Estefania, van Pee, Katharina, Yildiz, Özkan, Kühlbrandt, Werner, Müller, Daniel J., Hummer, Gerhard
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2019
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6613103/
https://ncbi.nlm.nih.gov/pubmed/31209022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1904304116
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