Positive Reinforcing Mechanisms Between GPR120 and PPARγ Modulate Insulin Sensitivity

G Protein-coupled receptor 120 (GPR120) and PPARγ agonists each have insulin sensitizing effects. But whether these two pathways functionally interact and can be leveraged together to markedly improve insulin resistance has not been explored. Here, we show that treatment with the PPARγ agonist rosig...

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Pubblicato in:Cell Metab
Autori principali: Paschoal, Vivian A., Walenta, Evelyn, Talukdar, Saswata, Pessentheiner, Ariane R., Osborn, Olivia, Hah, Nasun, Chi, Tyler J., Tye, George L., Armando, Aaron M., Evans, Ronald M., Chi, Nai-Wen, Quehenberger, Oswald, Olefsky, Jerrold M., Oh, Da Young
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7337476/
https://ncbi.nlm.nih.gov/pubmed/32413335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2020.04.020
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