Positive Reinforcing Mechanisms Between GPR120 and PPARγ Modulate Insulin Sensitivity

G Protein-coupled receptor 120 (GPR120) and PPARγ agonists each have insulin sensitizing effects. But whether these two pathways functionally interact and can be leveraged together to markedly improve insulin resistance has not been explored. Here, we show that treatment with the PPARγ agonist rosig...

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Veröffentlicht in:Cell Metab
Hauptverfasser: Paschoal, Vivian A., Walenta, Evelyn, Talukdar, Saswata, Pessentheiner, Ariane R., Osborn, Olivia, Hah, Nasun, Chi, Tyler J., Tye, George L., Armando, Aaron M., Evans, Ronald M., Chi, Nai-Wen, Quehenberger, Oswald, Olefsky, Jerrold M., Oh, Da Young
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7337476/
https://ncbi.nlm.nih.gov/pubmed/32413335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2020.04.020
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