A glycan cluster on the SARS-CoV-2 spike ectodomain is recognized by Fab-dimerized glycan-reactive antibodies

The COVID-19 pandemic caused by SARS-CoV-2 has escalated into a global crisis. The spike (S) protein that mediates cell entry and membrane fusion is the current focus of vaccine and therapeutic antibody development efforts. The S protein, like many other viral fusion proteins such as HIV-1 envelope...

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Veröffentlicht in:bioRxiv
Hauptverfasser: Acharya, Priyamvada, Williams, Wilton, Henderson, Rory, Janowska, Katarzyna, Manne, Kartik, Parks, Robert, Deyton, Margaret, Sprenz, Jordan, Stalls, Victoria, Kopp, Megan, Mansouri, Katayoun, Edwards, Robert J, Meyerhoff, R. Ryan, Oguin, Thomas, Sempowski, Gregory, Saunders, Kevin, Haynes, Barton F.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cold Spring Harbor Laboratory 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7337383/
https://ncbi.nlm.nih.gov/pubmed/32637953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2020.06.30.178897
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