Glycans on the SARS-CoV-2 Spike Control the Receptor Binding Domain Conformation

The glycan shield of the beta-coronavirus (β-CoV) Spike (S) glycoprotein provides protection from host immune responses, acting as a steric block to potentially neutralizing antibody responses. The conformationally dynamic S-protein is the primary immunogenic target of vaccine design owing to its ro...

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Veröffentlicht in:bioRxiv
Hauptverfasser: Henderson, Rory, Edwards, Robert J, Mansouri, Katayoun, Janowska, Katarzyna, Stalls, Victoria, Kopp, Megan, Haynes, Barton F., Acharya, Priyamvada
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cold Spring Harbor Laboratory 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7337389/
https://ncbi.nlm.nih.gov/pubmed/32637959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2020.06.26.173765
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