D614G Mutation Alters SARS-CoV-2 Spike Conformation and Enhances Protease Cleavage at the S1/S2 Junction

The severe acute respiratory coronavirus 2 (SARS-CoV-2) spike (S) protein is the target of vaccine design efforts to end the coronavirus disease 2019 (COVID-19) pandemic. Despite a low mutation rate, isolates with the D614G substitution in the S protein appeared early during the pandemic and are now...

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Veröffentlicht in:Cell Rep
Hauptverfasser: Gobeil, Sophie M.-C., Janowska, Katarzyna, McDowell, Shana, Mansouri, Katayoun, Parks, Robert, Manne, Kartik, Stalls, Victoria, Kopp, Megan F., Henderson, Rory, Edwards, Robert J., Haynes, Barton F., Acharya, Priyamvada
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Author(s). 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7762703/
https://ncbi.nlm.nih.gov/pubmed/33417835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2020.108630
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