Cold sensitivity of the SARS-CoV-2 spike ectodomain

The SARS-CoV-2 spike (S) protein, a primary target for COVID-19 vaccine development, presents its Receptor Binding Domain in two conformations: receptor-accessible “up” or receptor-inaccessible “down” conformations. Here, we report that the commonly used stabilized S ectodomain construct “2P” is sen...

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Pubblicato in:bioRxiv
Autori principali: Edwards, Robert J, Mansouri, Katayoun, Stalls, Victoria, Manne, Kartik, Watts, Brian, Parks, Rob, Janowska, Katarzyna, Gobeil, Sophie M. C., Kopp, Megan, Li, Dapeng, Lu, Xiaozhi, Mu, Zekun, Deyton, Margaret, Oguin, Thomas H, Sprenz, Jordan, Williams, Wilton, Saunders, Kevin, Montefiori, David, Sempowski, Gregory D., Henderson, Rory, Alam, Munir, Haynes, Barton F., Acharya, Priyamvada
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7373133/
https://ncbi.nlm.nih.gov/pubmed/32699852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2020.07.12.199588
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