Cold sensitivity of the SARS-CoV-2 spike ectodomain

The SARS-CoV-2 spike (S) protein, a primary target for COVID-19 vaccine development, presents its Receptor Binding Domain in two conformations: receptor-accessible “up” or receptor-inaccessible “down” conformations. Here, we report that the commonly used stabilized S ectodomain construct “2P” is sen...

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Detalhes bibliográficos
Publicado no:bioRxiv
Main Authors: Edwards, Robert J, Mansouri, Katayoun, Stalls, Victoria, Manne, Kartik, Watts, Brian, Parks, Rob, Janowska, Katarzyna, Gobeil, Sophie M. C., Kopp, Megan, Li, Dapeng, Lu, Xiaozhi, Mu, Zekun, Deyton, Margaret, Oguin, Thomas H, Sprenz, Jordan, Williams, Wilton, Saunders, Kevin, Montefiori, David, Sempowski, Gregory D., Henderson, Rory, Alam, Munir, Haynes, Barton F., Acharya, Priyamvada
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7373133/
https://ncbi.nlm.nih.gov/pubmed/32699852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2020.07.12.199588
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