Discovery of secondary sulphonamides as IDO1 inhibitors with potent antitumour effects in vivo

Indoleamine 2,3-dioxygenase 1 (IDO1) as a key rate-limiting enzyme in the kynurenine pathway of tryptophan metabolism plays an important role in tumour immune escape. Herein, a variety of secondary sulphonamides were synthesised and evaluated in the HeLa cell-based IDO1/kynurenine assay, leading to...

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Bibliographic Details
Published in:J Enzyme Inhib Med Chem
Main Authors: Ge, Shushan, Zhong, Haiqing, Ma, Xuewei, Zheng, Yingbo, Zou, Yi, Wang, Fang, Wang, Yan, Hu, Yue, Li, Yuezhen, Liu, Wen, Guo, Wenjie, Xu, Qiang, Lai, Yisheng
Format: Artigo
Language:Inglês
Published: Taylor & Francis 2020
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7336998/
https://ncbi.nlm.nih.gov/pubmed/32466694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2020.1765165
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