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Discovery of IDO1 inhibitors: from bench to bedside

Small molecule inhibitors of indoleamine 2,3-dioxygenase-1 (IDO1) are emerging at the vanguard of experimental agents in oncology. Here pioneers of this new drug class provide a bench-to-bedside review on preclinical validation of IDO1 as a cancer therapeutic target and on the discovery and developm...

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Publicat a:Cancer Res
Autors principals: Prendergast, George C., Malachowski, William P., DuHadaway, James B., Muller, Alexander J.
Format: Artigo
Idioma:Inglês
Publicat: 2017
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6021761/
https://ncbi.nlm.nih.gov/pubmed/29247038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-17-2285
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