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NLRC4 inflammasome activation is NLRP3- and phosphorylation-independent during infection and does not protect from melanoma
The NAIP/NLRC4 inflammasome is a cytosolic sensor of bacteria that activates caspase-1 and initiates potent immune responses. Structural, biochemical, and genetic data demonstrate that NAIP proteins are receptors for bacterial ligands, while NLRC4 is a downstream adaptor that multimerizes with NAIPs...
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| Publié dans: | J Exp Med |
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| Auteurs principaux: | , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Rockefeller University Press
2020
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7336302/ https://ncbi.nlm.nih.gov/pubmed/32342103 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20191736 |
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