NAIP-NLRC4 inflammasomes coordinate intestinal epithelial cell expulsion with eicosanoid and IL-18 release via activation of Caspase-1 and -8

Intestinal epithelial cells (IECs) form a critical barrier against pathogen invasion. By generation of mice in which inflammasome expression is restricted to IECs, we describe a coordinated epithelium-intrinsic inflammasome response in vivo. This response was sufficient to protect against Salmonella...

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Publicat a:Immunity
Autors principals: Rauch, Isabella, Deets, Katherine A., Ji, Daisy X., von Moltke, Jakob, Tenthorey, Jeannette L., Lee, Angus Y., Philip, Naomi H., Ayres, Janelle S., Brodsky, Igor E., Gronert, Karsten, Vance, Russell E.
Format: Artigo
Idioma:Inglês
Publicat: 2017
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5476318/
https://ncbi.nlm.nih.gov/pubmed/28410991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2017.03.016
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