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Molecular basis for specific recognition of bacterial ligands by NAIP/NLRC4 inflammasomes

NLR (nucleotide-binding domain [NBD]- and leucine-rich repeat [LRR]-containing) proteins mediate innate immune sensing of pathogens in mammals and plants. How NLRs detect their cognate stimuli remains poorly understood. Here, we analyzed ligand recognition by NAIP (NLR Apoptosis Inhibitory Protein)...

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Detalhes bibliográficos
Main Authors: Tenthorey, Jeannette L., Kofoed, Eric M., Daugherty, Matthew D., Malik, Harmit S., Vance, Russell E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3988258/
https://ncbi.nlm.nih.gov/pubmed/24657167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2014.02.018
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