Efficient gene knockout in primary human and murine myeloid cells by non-viral delivery of CRISPR-Cas9

Myeloid cells play critical and diverse roles in mammalian physiology, including tissue development and repair, innate defense against pathogens, and generation of adaptive immunity. As cells that show prolonged recruitment to sites of injury or pathology, myeloid cells represent therapeutic targets...

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Publicado en:J Exp Med
Autores principales: Freund, Emily C., Lock, Jaclyn Y., Oh, Jaehak, Maculins, Timurs, Delamarre, Lelia, Bohlen, Christopher J., Haley, Benjamin, Murthy, Aditya
Formato: Artigo
Lenguaje:Inglês
Publicado: Rockefeller University Press 2020
Materias:
Technical Advances and Resources
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7336301/
https://ncbi.nlm.nih.gov/pubmed/32357367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20191692
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