Efficient gene knockout in primary human and murine myeloid cells by non-viral delivery of CRISPR-Cas9

Myeloid cells play critical and diverse roles in mammalian physiology, including tissue development and repair, innate defense against pathogens, and generation of adaptive immunity. As cells that show prolonged recruitment to sites of injury or pathology, myeloid cells represent therapeutic targets...

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Bibliografische gegevens
Gepubliceerd in:J Exp Med
Hoofdauteurs: Freund, Emily C., Lock, Jaclyn Y., Oh, Jaehak, Maculins, Timurs, Delamarre, Lelia, Bohlen, Christopher J., Haley, Benjamin, Murthy, Aditya
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Rockefeller University Press 2020
Onderwerpen:
Technical Advances and Resources
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7336301/
https://ncbi.nlm.nih.gov/pubmed/32357367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20191692
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