Merkel cell polyomavirus activates LSD1-mediated blockade of non-canonical BAF to regulate transformation and tumorigenesis

Merkel cell carcinoma (MCC), a neuroendocrine cancer of the skin, is caused by integration of Merkel cell polyomavirus (MCV) and persistent expression of Large T antigen (LT) and Small T antigen (ST). We report that ST in complex with MYCL and the EP400 complex activates expression of LSD1 (KDM1A),...

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Pubblicato in:Nat Cell Biol
Autori principali: Park, Donglim Esther, Cheng, Jingwei, McGrath, John P., Lim, Matthew Y., Cushman, Camille, Swanson, Selene K., Tillgren, Michelle L., Paulo, Joao A., Gokhale, Prafulla C., Florens, Laurence, Washburn, Michael P., Trojer, Patrick, DeCaprio, James A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7336275/
https://ncbi.nlm.nih.gov/pubmed/32284543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41556-020-0503-2
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