Merkel cell polyomavirus activates LSD1-mediated blockade of non-canonical BAF to regulate transformation and tumorigenesis

Merkel cell carcinoma (MCC), a neuroendocrine cancer of the skin, is caused by integration of Merkel cell polyomavirus (MCV) and persistent expression of Large T antigen (LT) and Small T antigen (ST). We report that ST in complex with MYCL and the EP400 complex activates expression of LSD1 (KDM1A),...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Nat Cell Biol
मुख्य लेखकों: Park, Donglim Esther, Cheng, Jingwei, McGrath, John P., Lim, Matthew Y., Cushman, Camille, Swanson, Selene K., Tillgren, Michelle L., Paulo, Joao A., Gokhale, Prafulla C., Florens, Laurence, Washburn, Michael P., Trojer, Patrick, DeCaprio, James A.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: 2020
विषय:
Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC7336275/
https://ncbi.nlm.nih.gov/pubmed/32284543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41556-020-0503-2
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