Merkel Cell Polyomavirus Large T Antigen Has Growth-Promoting and Inhibitory Activities

Merkel cell carcinoma (MCC) is a rare and aggressive form of skin cancer. In at least 80% of all MCC, Merkel cell polyomavirus (MCPyV) DNA has undergone clonal integration into the host cell genome, and most tumors express the MCPyV large and small T antigens. In all cases of MCC reported to date, t...

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Bibliographic Details
Main Authors: Cheng, Jingwei, Rozenblatt-Rosen, Orit, Paulson, Kelly G., Nghiem, Paul, DeCaprio, James A.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2013
Subjects:
Transformation and Oncogenesis
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3648111/
https://ncbi.nlm.nih.gov/pubmed/23514892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00385-13
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