Merkel cell polyomavirus recruits MYCL to the EP400 complex to promote oncogenesis

Merkel cell carcinoma (MCC) frequently contains integrated copies of Merkel cell polyomavirus DNA that express a truncated form of Large T antigen (LT) and an intact Small T antigen (ST). While LT binds RB and inactivates its tumor suppressor function, it is less clear how ST contributes to MCC tumo...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Cheng, Jingwei, Park, Donglim Esther, Berrios, Christian, White, Elizabeth A., Arora, Reety, Yoon, Rosa, Branigan, Timothy, Xiao, Tengfei, Westerling, Thomas, Federation, Alexander, Zeid, Rhamy, Strober, Benjamin, Swanson, Selene K., Florens, Laurence, Bradner, James E., Brown, Myles, Howley, Peter M., Padi, Megha, Washburn, Michael P., DeCaprio, James A.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5640240/
https://ncbi.nlm.nih.gov/pubmed/29028833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006668
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