Dietary glutamine supplementation suppresses epigenetically-activated oncogenic pathways to inhibit melanoma tumour growth

Tumour cells adapt to nutrient deprivation in vivo, yet strategies targeting the nutrient poor microenvironment remain unexplored. In melanoma, tumour cells often experience low glutamine levels, which promote cell dedifferentiation. Here, we show that dietary glutamine supplementation significantly...

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Publicado en:Nat Commun
Main Authors: Ishak Gabra, Mari B., Yang, Ying, Li, Haiqing, Senapati, Parijat, Hanse, Eric A., Lowman, Xazmin H., Tran, Thai Q., Zhang, Lishi, Doan, Linda T., Xu, Xiangdong, Schones, Dustin E., Fruman, David A., Kong, Mei
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7335172/
https://ncbi.nlm.nih.gov/pubmed/32620791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-17181-w
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