Mechanistic insights into chromatin targeting by leukemic NUP98-PHF23 fusion

Chromosomal NUP98-PHF23 translocation is associated with an aggressive form of acute myeloid leukemia (AML) and poor survival rate. Here, we report the molecular mechanisms by which NUP98-PHF23 recognizes the histone mark H3K4me3 and is inhibited by small molecule compounds, including disulfiram tha...

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Gepubliceerd in:Nat Commun
Hoofdauteurs: Zhang, Yi, Guo, Yiran, Gough, Sheryl M., Zhang, Jinyong, Vann, Kendra R., Li, Kuai, Cai, Ling, Shi, Xiaobing, Aplan, Peter D., Wang, Gang Greg, Kutateladze, Tatiana G.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2020
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7335091/
https://ncbi.nlm.nih.gov/pubmed/32620764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-17098-4
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