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Mechanistic insights into chromatin targeting by leukemic NUP98-PHF23 fusion
Chromosomal NUP98-PHF23 translocation is associated with an aggressive form of acute myeloid leukemia (AML) and poor survival rate. Here, we report the molecular mechanisms by which NUP98-PHF23 recognizes the histone mark H3K4me3 and is inhibited by small molecule compounds, including disulfiram tha...
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| 出版年: | Nat Commun |
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| 主要な著者: | , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group UK
2020
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7335091/ https://ncbi.nlm.nih.gov/pubmed/32620764 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-17098-4 |
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