mTOR Complexes Repress Hypertrophic Agonist-Stimulated Expression of Connective Tissue Growth Factor in Adult Cardiac Muscle Cells

Connective tissue growth factor (CTGF) is a fibrogenic cytokine that promotes fibrosis in various organs. In the heart, both cardiomyocytes (CM) and cardiac fibroblasts (CFb) have been reported as a source of CTGF expression, aiding cardiac fibrosis. Since the mammalian target of rapamycin (mTOR) fo...

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Detalles Bibliográficos
Publicado en:J Cardiovasc Pharmacol
Main Authors: Sundararaj, Kamala, Pleasant, Dorea L., Moschella, Phillip C., Panneerselvam, Kavin, Balasubramanian, Sundaravadivel, Kuppuswamy, Dhandapani
Formato: Artigo
Idioma:Inglês
Publicado: 2016
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7334753/
https://ncbi.nlm.nih.gov/pubmed/26371948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FJC.0000000000000322
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