ALS/FTD mutations in UBQLN2 impede autophagy by reducing autophagosome acidification through loss of function

Mutations in UBQLN2 cause amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and other neurodegenerations. However, the mechanism by which the UBQLN2 mutations cause disease remains unclear. Alterations in proteins involved in autophagy are prominent in neuronal tissue of human ALS...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Proc Natl Acad Sci U S A
Egile Nagusiak: Wu, Josephine J., Cai, Ashley, Greenslade, Jessie E., Higgins, Nicole R., Fan, Cong, Le, Nhat T. T., Tatman, Micaela, Whiteley, Alexandra M., Prado, Miguel A., Dieriks, Birger V., Curtis, Maurice A., Shaw, Christopher E., Siddique, Teepu, Faull, Richard L. M., Scotter, Emma L., Finley, Daniel, Monteiro, Mervyn J.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: National Academy of Sciences 2020
Gaiak:
Biological Sciences
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7334651/
https://ncbi.nlm.nih.gov/pubmed/32513711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1917371117
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