Exploring the structural basis of conformational heterogeneity and autoinhibition of human cGMP-specific protein kinase Iα through computational modelling and molecular dynamics simulations

Protein kinase Iα (PKGIα) is a pivotal cyclic guanosine monophosphate (cGMP) signalling protein. Major steps related to the structural plasticity of PKGIα have been inferred but the structural aspects of the auto-inhibition and multidomain tertiary organization of human PKGIα in active and inactive...

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Detaylı Bibliyografya
Yayımlandı:Comput Struct Biotechnol J
Asıl Yazarlar: Maryam, Arooma, Khalid, Rana Rehan, Vedithi, Sundeep Chaitanya, ECE, Abdulilah, Çınaroğlu, Suleyman Selim, Siddiqi, Abdul Rauf, Blundell, Tom L.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Research Network of Computational and Structural Biotechnology 2020
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7334484/
https://ncbi.nlm.nih.gov/pubmed/32670503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.csbj.2020.06.016
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