Učitavanje...
Structure-guided engineering of the affinity and specificity of CARs against Tn-glycopeptides
The potency of adoptive T cell therapies targeting the cell surface antigen CD19 has been demonstrated in hematopoietic cancers. It has been difficult to identify appropriate targets in nonhematopoietic tumors, but one class of antigens that have shown promise is aberrant O-glycoprotein epitopes. It...
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| Izdano u: | Proc Natl Acad Sci U S A |
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| Glavni autori: | , , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
National Academy of Sciences
2020
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7334454/ https://ncbi.nlm.nih.gov/pubmed/32541028 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1920662117 |
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