Structure-guided engineering of the affinity and specificity of CARs against Tn-glycopeptides

The potency of adoptive T cell therapies targeting the cell surface antigen CD19 has been demonstrated in hematopoietic cancers. It has been difficult to identify appropriate targets in nonhematopoietic tumors, but one class of antigens that have shown promise is aberrant O-glycoprotein epitopes. It...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Proc Natl Acad Sci U S A
Egile Nagusiak: Sharma, Preeti, Marada, Venkata V. V. R., Cai, Qi, Kizerwetter, Monika, He, Yanran, Wolf, Steven P., Schreiber, Karin, Clausen, Henrik, Schreiber, Hans, Kranz, David M.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: National Academy of Sciences 2020
Gaiak:
Biological Sciences
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7334454/
https://ncbi.nlm.nih.gov/pubmed/32541028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1920662117
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