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Engineered CAR T Cells Targeting the Cancer-Associated Tn-Glycoform of the Membrane Mucin MUC1 Control Adenocarcinoma

Genetically modified T cells expressing chimeric antigen receptors (CARs) demonstrate robust responses against lineage restricted, non-essential targets in hematologic cancers. However, in solid tumors, the full potential of CAR T cell therapy is limited by the availability of cell surface antigens...

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Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:	Immunity
Κύριοι συγγραφείς:	Posey, Avery D., Schwab, Robert D., Boesteanu, Alina C., Steentoft, Catharina, Mandel, Ulla, Engels, Boris, Stone, Jennifer D., Madsen, Thomas D., Schreiber, Karin, Haines, Kathleen M., Cogdill, Alexandria P., Chen, Taylor J., Song, Decheng, Scholler, John, Kranz, David M., Feldman, Michael D., Young, Regina, Keith, Brian, Schreiber, Hans, Clausen, Henrik, Johnson, Laura A., June, Carl H.
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	2016
Θέματα:	Article
Διαθέσιμο Online:	https://ncbi.nlm.nih.gov/pmc/articles/PMC5358667/ https://ncbi.nlm.nih.gov/pubmed/27332733 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2016.05.014
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Engineered CAR T Cells Targeting the Cancer-Associated Tn-Glycoform of the Membrane Mucin MUC1 Control Adenocarcinoma

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