Multiple cancer-specific antigens are targeted by a chimeric antigen receptor on a single cancer cell

Human cancer cells were eradicated by adoptive transfer of T cells transduced with a chimeric antigen receptor (CAR) made from an antibody (237Ab) that is highly specific for the murine Tn-glycosylated podoplanin (Tn-PDPN). The objectives were to determine the specificity of these CAR-transduced T (...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: He, Yanran, Schreiber, Karin, Wolf, Steven P., Wen, Frank, Steentoft, Catharina, Zerweck, Jonathan, Steiner, Madeline, Sharma, Preeti, Shepard, H. Michael, Posey, Avery, June, Carl H., Mandel, Ulla, Clausen, Henrik, Leisegang, Matthias, Meredith, Stephen C., Kranz, David M., Schreiber, Hans
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6948763/
https://ncbi.nlm.nih.gov/pubmed/31672936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.130416
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