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Structure of a DNA polymerase abortive complex with the 8OG:dA base pair at the primer terminus
Adenine frequently pairs with the Hoogsteen edge of an oxidized guanine base (8OG) causing G to T transversions. The (syn)8OG:dA base pair is indistinguishable from the cognant base pair and can be extended by DNA polymerases with reduced efficiency. To examine the structural basis of this reduced e...
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| Publicat a: | Commun Biol |
|---|---|
| Autors principals: | , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Publishing Group UK
2020
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7334213/ https://ncbi.nlm.nih.gov/pubmed/32620932 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-020-1080-4 |
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