Constitutive activation of RAS/MAPK pathway cooperates with trisomy 21 and is therapeutically exploitable in Down syndrome B-cell Leukemia

PURPOSE: Children with Down syndrome (DS, constitutive trisomy 21) that develop acute lymphoblastic leukemia (DS-ALL) have a 3-fold increased likelihood of treatment-related mortality coupled with a higher cumulative incidence of relapse, compared to other children with B-cell acute lymphoblastic le...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Laurent, Anouchka P., Siret, Aurélie, Ignacimouttou, Cathy, Panchal, Kunjal, Diop, M’Boyba K., Jenny, Silvia, Tsai, Yi-Chien, Ross-Weil, Damien, Aid, Zakia, Prade, Naïs, Lagarde, Stéphanie, Plassard, Damien, Pierron, Gaelle, Daudigeos-Dubus, Estelle, Lecluse, Yann, Droin, Nathalie, Bornhauser, Beat, Cheung, Laurence C., Crispino, John D., Gaudry, Muriel, Bernard, Olivier A., Macintyre, Elizabeth, Bonnigal, Carole Barin, Kotecha, Rishi S., Geoerger, Birgit, Ballerini, Paola, Bourquin, Jean-Pierre, Delabesse, Eric, Mercher, Thomas, Malinge, Sébastien
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7334063/
https://ncbi.nlm.nih.gov/pubmed/32220889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-19-3519
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