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Histone deacetylase inhibitor panobinostat induces antitumor activity in epithelioid sarcoma and rhabdoid tumor by growth factor receptor modulation

BACKGROUND: Epithelioid sarcomas and rhabdoid tumors are rare, aggressive malignancies with poor prognosis. Both are characterized by INI1 alterations and deregulation of growth factor receptors albeit their interaction has not been elucidated. METHODS: In this study, we investigated the activity of...

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Detalhes bibliográficos
Publicado no:BMC Cancer
Main Authors: Harttrampf, Anne Catherine, da Costa, Maria Eugenia Marques, Renoult, Aline, Daudigeos-Dubus, Estelle, Geoerger, Birgit
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2021
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8290558/
https://ncbi.nlm.nih.gov/pubmed/34281526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-021-08579-w
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