Partial trisomy 21 contributes to T-cell malignancies induced by JAK3-activating mutations in murine models

JAK3-activating mutations are commonly seen in chronic or acute hematologic malignancies affecting the myeloid, megakaryocytic, lymphoid, and natural killer (NK) cell compartment. Overexpression models of mutant JAK3 or pharmacologic inhibition of its kinase activity have highlighted the role that t...

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Detalles Bibliográficos
Publicado en:Blood Adv
Main Authors: Rivera-Munoz, Paola, Laurent, Anouchka P., Siret, Aurelie, Lopez, Cecile K., Ignacimouttou, Cathy, Cornejo, Melanie G., Bawa, Olivia, Rameau, Philippe, Bernard, Olivier A., Dessen, Philippe, Gilliland, Gary D., Mercher, Thomas, Malinge, Sébastien
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Hematology 2018
Assuntos:
Lymphoid Neoplasia
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6039658/
https://ncbi.nlm.nih.gov/pubmed/29986854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2018016089
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