RICTOR/mTORC2 affects tumorigenesis and therapeutic efficacy of mTOR inhibitors in esophageal squamous cell carcinoma

Dysregulation of mTORC1/mTORC2 pathway is observed in many cancers and mTORC1 inhibitors have been used clinically in many tumor types; however, the mechanism of mTORC2 in tumorigenesis is still obscure. Here, we mainly explored the potential role of mTORC2 in esophageal squamous cell carcinoma (ESC...

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Detalhes bibliográficos
Publicado no:Acta Pharm Sin B
Main Authors: Lu, Zhaoming, Shi, Xiaojing, Gong, Fanghua, Li, Shenglei, Wang, Yang, Ren, Yandan, Zhang, Mengyin, Yu, Bin, Li, Yan, Zhao, Wen, Zhang, Jianying, Hou, Guiqin
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020
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Original article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7332809/
https://ncbi.nlm.nih.gov/pubmed/32642408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.apsb.2020.01.010
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