MALT1 targeting suppresses CARD14‐induced psoriatic dermatitis in mice

CARD14 gain‐of‐function mutations cause psoriasis in humans and mice. Together with BCL10 and the protease MALT1, mutant CARD14 forms a signaling node that mediates increased NF‐κB signaling and proinflammatory gene expression in keratinocytes. However, it remains unclear whether psoriasis in respon...

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Bibliografske podrobnosti
izdano v:EMBO Rep
Main Authors: Van Nuffel, Elien, Staal, Jens, Baudelet, Griet, Haegman, Mira, Driege, Yasmine, Hochepied, Tino, Afonina, Inna S, Beyaert, Rudi
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2020
Teme:
Reports
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7332803/
https://ncbi.nlm.nih.gov/pubmed/32343482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201949237
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