Overexpression of HGF/MET axis along with p53 inhibition induces de novo glioma formation in mice

BACKGROUND: Aberrant MET receptor tyrosine kinase (RTK) activation leads to invasive tumor growth in different types of cancer. Overexpression of MET and its ligand hepatocyte growth factor (HGF) occurs more frequently in glioblastoma (GBM) than in low-grade gliomas. Although we have shown previousl...

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Bibliografiske detaljer
Udgivet i:Neurooncol Adv
Main Authors: Qin, Yuan, Musket, Anna, Kou, Jianqun, Preiszner, Johanna, Tschida, Barbara R, Qin, Anna, Land, Craig A, Staal, Ben, Kang, Liang, Tanner, Kirk, Jiang, Yong, Schweitzer, John B, Largaespada, David A, Xie, Qian
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2020
Fag:
Basic and Translational Investigations
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7332240/
https://ncbi.nlm.nih.gov/pubmed/32642717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/noajnl/vdaa067
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