Overexpression of HGF/MET axis along with p53 inhibition induces de novo glioma formation in mice

BACKGROUND: Aberrant MET receptor tyrosine kinase (RTK) activation leads to invasive tumor growth in different types of cancer. Overexpression of MET and its ligand hepatocyte growth factor (HGF) occurs more frequently in glioblastoma (GBM) than in low-grade gliomas. Although we have shown previousl...

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Detalhes bibliográficos
Publicado no:Neurooncol Adv
Main Authors: Qin, Yuan, Musket, Anna, Kou, Jianqun, Preiszner, Johanna, Tschida, Barbara R, Qin, Anna, Land, Craig A, Staal, Ben, Kang, Liang, Tanner, Kirk, Jiang, Yong, Schweitzer, John B, Largaespada, David A, Xie, Qian
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Basic and Translational Investigations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7332240/
https://ncbi.nlm.nih.gov/pubmed/32642717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/noajnl/vdaa067
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