The zinc-finger protein ZFYVE1 modulates TLR3-mediated signaling by facilitating TLR3 ligand binding

Recognition of viral dsRNA by Toll-like receptor 3 (TLR3) leads to the induction of downstream antiviral effectors and the innate antiviral immune response. Here, we identified the zinc-finger FYVE domain-containing protein ZFYVE1, a guanylate-binding protein (GBP), as a positive regulator of TLR3-m...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cell Mol Immunol
Prif Awduron: Zhong, Xuan, Feng, Lu, Xu, Wen-Hua, Wu, Xin, Ding, Yi-Di, Zhou, Yan, Lei, Cao-Qi, Shu, Hong-Bing
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2019
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7331751/
https://ncbi.nlm.nih.gov/pubmed/31388100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41423-019-0265-6
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