Varying Effects of APOE Alleles on Extreme Longevity in European Ethnicities

APOE is a well-studied gene with multiple effects on aging and longevity. The gene has three alleles: e2, e3, and e4, whose frequencies vary by ethnicity. While the e2 is associated with healthy cognitive aging, the e4 allele is associated with Alzheimer’s disease and early mortality and therefore i...

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Udgivet i:J Gerontol A Biol Sci Med Sci
Main Authors: Gurinovich, Anastasia, Andersen, Stacy L, Puca, Annibale, Atzmon, Gil, Barzilai, Nir, Sebastiani, Paola
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2019
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Supplement Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7330482/
https://ncbi.nlm.nih.gov/pubmed/31724059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/gerona/glz179
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