Impact of concurrent genomic alterations in epidermal growth factor receptor (EGFR)-mutated lung cancer

Comprehensive characterization of the genomic landscape of epidermal growth factor receptor (EGFR)-mutated lung cancers have identified patterns of secondary mutations beyond the primary oncogenic EGFR mutation. These include concurrent pathogenic alterations affecting p53 (60–65%), RTKs (5–10%), PI...

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Dettagli Bibliografici
Pubblicato in:J Thorac Dis
Autori principali: Gini, Beatrice, Thomas, Nicholas, Blakely, Collin M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: AME Publishing Company 2020
Soggetti:
Review Article on Mechanisms of Resistance to EGFR-targeted Therapy
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7330397/
https://ncbi.nlm.nih.gov/pubmed/32642201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.21037/jtd.2020.03.78
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