Impact of concurrent genomic alterations in epidermal growth factor receptor (EGFR)-mutated lung cancer

Comprehensive characterization of the genomic landscape of epidermal growth factor receptor (EGFR)-mutated lung cancers have identified patterns of secondary mutations beyond the primary oncogenic EGFR mutation. These include concurrent pathogenic alterations affecting p53 (60–65%), RTKs (5–10%), PI...

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Detalles Bibliográficos
Publicado en:J Thorac Dis
Main Authors: Gini, Beatrice, Thomas, Nicholas, Blakely, Collin M.
Formato: Artigo
Idioma:Inglês
Publicado: AME Publishing Company 2020
Assuntos:
Review Article on Mechanisms of Resistance to EGFR-targeted Therapy
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7330397/
https://ncbi.nlm.nih.gov/pubmed/32642201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.21037/jtd.2020.03.78
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