Development of AAV Variants with Human Hepatocyte Tropism and Neutralizing Antibody Escape Capacity

Adeno-associated virus (AAV) vectors have been successfully used in patients with bleeding disorders and blindness. For human liver targeting, two major factors restrict effective AAV transduction after systemic administration of AAV vectors: human hepatocyte tropism and neutralizing antibodies (Nab...

Full description

Saved in:
Bibliographic Details
Published in:Mol Ther Methods Clin Dev
Main Authors: Pei, Xiaolei, Shao, Wenwei, Xing, Allene, Askew, Charles, Chen, Xiaojing, Cui, Caibin, Abajas, Yasmina L., Gerber, David A., Merricks, Elizabeth P., Nichols, Timothy C., Li, Wuping, Samulski, R. Jude, Li, Chengwen
Format: Artigo
Language:Inglês
Published: American Society of Gene & Cell Therapy 2020
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7329936/
https://ncbi.nlm.nih.gov/pubmed/32637455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2020.06.003
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items