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Nab Escaping AAV Mutants Isolated from Mouse Muscles

Neutralizing antibodies (Nabs) are a major challenge in clinical trials of adeno-associated virus (AAV) vector gene therapy, because Nabs are able to inhibit AAV transduction in patients. We have successfully isolated several novel Nab-escaped AAV chimeric capsids in mice by administrating a mixture...

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Detalhes bibliográficos
Publicado no:Bio Protoc
Main Authors: Chai, Zheng, Samulski, Jude R., Li, Chengwen
Formato: Artigo
Idioma:Inglês
Publicado em: Bio-Protocol 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6018009/
https://ncbi.nlm.nih.gov/pubmed/29951572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.21769/BioProtoc.2841
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