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Nab Escaping AAV Mutants Isolated from Mouse Muscles
Neutralizing antibodies (Nabs) are a major challenge in clinical trials of adeno-associated virus (AAV) vector gene therapy, because Nabs are able to inhibit AAV transduction in patients. We have successfully isolated several novel Nab-escaped AAV chimeric capsids in mice by administrating a mixture...
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| Published in: | Bio Protoc |
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| Main Authors: | , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
Bio-Protocol
2018
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6018009/ https://ncbi.nlm.nih.gov/pubmed/29951572 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.21769/BioProtoc.2841 |
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