Complete Reconstitution and Deorphanization of the 3 MDa Nocardiosis-Associated Polyketide Synthase

Several Nocardia strains associated with nocardiosis, a potentially life-threatening disease, house a nonamodular assembly line polyketide synthase (PKS) that presumably synthesizes an unknown polyketide. Here, we report the discovery and structure elucidation of the NOCAP (nocardiosis-associated po...

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Gepubliceerd in:J Am Chem Soc
Hoofdauteurs: Yuet, Kai P., Liu, Corey W., Lynch, Stephen R., Kuo, James, Michaels, Wesley, Lee, Robert B., McShane, Abigail E., Zhong, Brian L., Fischer, Curt R., Khosla, Chaitan
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2020
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7329362/
https://ncbi.nlm.nih.gov/pubmed/32182063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.0c00904
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