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Complete Reconstitution and Deorphanization of the 3 MDa Nocardiosis-Associated Polyketide Synthase
Several Nocardia strains associated with nocardiosis, a potentially life-threatening disease, house a nonamodular assembly line polyketide synthase (PKS) that presumably synthesizes an unknown polyketide. Here, we report the discovery and structure elucidation of the NOCAP (nocardiosis-associated po...
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| Publicado no: | J Am Chem Soc |
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| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7329362/ https://ncbi.nlm.nih.gov/pubmed/32182063 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.0c00904 |
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