Agonist-specific desensitization of PGE(2)-stimulated cAMP signaling due to upregulated phosphodiesterase expression in human lung fibroblasts

Pulmonary fibrosis is characterized by fibroblasts persisting in an activated form, producing excessive fibrous material that destroys alveolar structure. The second messenger molecule cyclic 3′,5′-adenosine monophosphate (cAMP) has antifibrotic properties, and prostaglandin E(2) (PGE(2)) can stimul...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Naunyn Schmiedebergs Arch Pharmacol
Main Authors: Nunez, Francisco J., Schulte, Nancy A., Fogel, David M., Michalski, Joel, Rennard, Stephen I., Penn, Raymond B., Toews, Myron L., Ostrom, Rennolds S
Format: Artigo
Sprog:Inglês
Udgivet: 2019
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7328663/
https://ncbi.nlm.nih.gov/pubmed/31884570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00210-019-01800-5
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker