Agonist-specific desensitization of PGE(2)-stimulated cAMP signaling due to upregulated phosphodiesterase expression in human lung fibroblasts

Pulmonary fibrosis is characterized by fibroblasts persisting in an activated form, producing excessive fibrous material that destroys alveolar structure. The second messenger molecule cyclic 3′,5′-adenosine monophosphate (cAMP) has antifibrotic properties, and prostaglandin E(2) (PGE(2)) can stimul...

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Detalhes bibliográficos
Publicado no:Naunyn Schmiedebergs Arch Pharmacol
Main Authors: Nunez, Francisco J., Schulte, Nancy A., Fogel, David M., Michalski, Joel, Rennard, Stephen I., Penn, Raymond B., Toews, Myron L., Ostrom, Rennolds S
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7328663/
https://ncbi.nlm.nih.gov/pubmed/31884570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00210-019-01800-5
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